Sodium Glucose Cotransport-2 Inhibition and Intrarenal RAS Activity in People With Type 1 Diabetes
The association between GLP-1 receptor agonists and diabetic retinopathy progression gained significant attention following the SUSTAIN-6 trial, published in 2016
It plays a crucial role in neutralizing free radicals, reducing inflammation, and supporting the immune system
However, when a third of the participants were switched to a placebo for the following year, they regained 7% of the weight they had lost
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GLP-1 and GLP-1 RA (such as Exenatide and Liraglutide) were shown to have an anti-inflammatory action by reducing monocyte adhesion and macrophage accumulation, thus stabilizing atherosclerotic plaque, and slowing atherosclerosis in animal models [47,48,49]