Patients with history of pancreatitis, severe gastrointestinal disease, or who are pregnant or planning pregnancy should discuss risks with their healthcare provider
GLP-1 agonists (like semaglutide) and dual GLP-1/GIP agonists (like tirzepatide) work by mimicking natural hormones that regulate your appetite and digestion
Sometimes these medications are prescribed together under close medical supervision, but combining them can increase the risk of low blood pressure and slow heart rate
Many prescribe other brands of semaglutide, such as Ozempic and Rybelsus, off-label (using a drug that is FDA-approved for a different reason)
However, native GLP-1 has a very short half-life because it is rapidly degraded by the enzyme DPP-4, which limits its therapeutic use
When it comes to the meeting, I think this is a disaster in the works, because these peptides have no data to support their safety and efficacy, Dr