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Back to Journals Diabetes, Metabolic Syndrome and Obesity Volume 19 GLP-1 Agonists in Adolescent Obesity: A Narrative Review of Single, Dual, and Triple Agonists Authors Abid M, Sheikh KS, Ahmad MS, Jiang H Received 19 January 2026 Accepted for publication 17 March 2026 Published 12 June 2026 Volume 2026:19 566414 DOI Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Donald McClain Mahroz Abid, 1 Khizer Sohail Sheikh, 1 Muhammad Shahbaz Ahmad, 2 Hongwei Jiang 1 1 Department of Metabolism and Endocrinology, Endocrine and Metabolic Disease Center, The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Peoples Republic of China

10.1016/j.freeradbiomed.2017.10.372 106 SugiuraT.KatoS.ShimizuT.WakayamaT.NakamichiN.KuboY.et al (2010)

Titration: If further glycemic control is required after at least 30 days on 7mg/daily, the dose may be increased to 14mg orally once daily

Spacing divided doses throughout the day can help maintain more consistent blood levels

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BPC-157: More localized, especially in the GI tract and connective tissue TB-500: Broader systemic effects, influencing cell migration and circulation In some cases, both may be considered together (bpc157 and tb500) as complementary, though decisions must be individualized and physician-guided