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To counteract this lipid peroxidation, cells rely on antioxidant defenses centered around GPX4 and NADPH-ferroptosis suppressor protein 1 (FSP1)

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Although the paper does not outline specific criteria for identifying patients who might deteriorate significantly, some combination of dose ingested, time of ingestion, specific form of VPA involved (long-acting preparations pose an increased risk of continued delayed absorption), serum VPA level on presentation, and symptoms should be considered

Details of the subgroup analyses are shown in Fig 4