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All aorta and liver histology analysis was performed in a blinded manner

,,GhanbariF,HasaniSAghiliZSet al.The potential preventive effect of probiotics, prebiotics, and synbiotics on cardiovascular risk factors through modulation of gut microbiota: A review.2024;12(7):45694580

The National Health and Nutrition Examination Survey estimated that 3.2% of adults over age 50 have a seriously low B12 level, and up to 20% may have a borderline deficiency

Discussion This study found that use of GLP-1 agonists for weight loss compared with use of bupropion-naltrexone was associated with increased risk of pancreatitis, gastroparesis, and bowel obstruction but not biliary disease

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There is no control group (patients receiving a placebo), no randomisation, and selection criteria may introduce bias