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Preclinical toxicology in standard models reports low acute toxicity at studied doses, but absence of extensive human clinical trial data precludes definitive statements on safety, tolerability, drug interactions, and longterm effects in humans

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However, given the patients rapidly deteriorating general condition, altered consciousness, tachypnea, and respiratory muscle fatigue, a decision was made to transfer him to the intensive care unit, where continuous veno-venous hemodiafiltration (CVVHDF) therapy was immediately initiated and continued for 48 hours with gradual resolution of acidosis symptoms and normalization of blood gas parameters