In Phase II , the liver needs to neutralize those "shards" so they can be safely removed from the body
Nicolay JP, Liebig G, Niemoeller OM, Koka S, Ghashghaeinia M, Wieder T, et al
it does NOT prove that one directly causes the other
The relationship between GLP-1 therapy and depression remains an active area of clinical investigation, with recent data suggesting the risk may vary based on individual biology and baseline mental health status
GLP-1 agonists and infertility: Mechanistic insights and clinical evidence
Oprah Winfrey had famously been trying to lose weight on and off for decades, then found the drugs and whoosh it was gone