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In a phase 2 trial of obese subjects, cagrilintide used in different subcutaneous doses once weekly was associated with a mean weight loss of 6-10.8% after 26 weeks, compared with 9.0% with the glucagon-like 1 receptor (GLP-1R) liraglutide (3 mg/d) and 3% with placebo at 26 weeks

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10.1124/jpet.103.051987 161

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The glucagon receptor component has been a particular focus of mechanistic investigation

In experiments using human SH-SY5Y neuroblastoma cells, IGF-1 can modulate the expression of genes that are altered in schizophrenia, normalizing their expression levels (121)