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10.3389/fphys.2020.00694 Front Physiol

Corejova et al., As has been summarized previously, early studies in ASD demonstrated central deficiencies in BH4 and both controlled and open-label trials demonstrate a therapeutic effect of sapropterin in children with ASD (Frye et al., Some of the first cases of cerebral folate deficiency (CFD) were identified to have features of ASD (Ramaekers et al., 2005)

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355 Physiological levels of ammonium in the blood are about 1020 M, but following liver failure ammonium rise to millimolar levels