M., Hnggi, G., Innocenti, M., & Elsner, P
That rationale must be backed by non-clinical data confirming the compound behaves as expected and by a thorough safety and toxicology program that identifies potential risks and establishes a safe starting dose for the first human administration and the maximum human exposure that should not be surpassed
For more than two decades, researchers pursued the goal of delivering GLP-1 receptor activation through an oral tablet, a pursuit complicated by the fundamental biochemistry of peptide drugs: their vulnerability to acid hydrolysis in the stomach, enzymatic degradation in the gastrointestinal tract, and poor absorption across the intestinal epithelium
Adverse effects of VPA overdose, lethargy, coma, and respiratory depression, are caused not only by the drug itself but also by active metabolites formed via - and -oxidation
Jej kluczowa funkcja biochemiczna jest jasno okrelona: karnityna peni rol transportera - przenosi dugoacuchowe kwasy tuszczowe przez wewntrzn bon mitochondriw, gdzie nastpnie mog by utlenione (beta-oksydacja) i przeksztacone w energi w postaci ATP
Metabolism: Clinical and Experimental, 57 (5), 712-717
