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Results Construct design for selecting high-GSH cells As cellular GSH is known to feedback inhibit expression from the GSH1 promoter ( pGSH1 ) [30], we designed a feedback loop for enrichment of high-GSH producing cells within clonal yeast cultures (Fig

Elevated cyclic AMP can activate downstream signaling intermediates including protein kinase A and related phosphorylation cascades that regulate gene transcription and cellular metabolic responses

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After age 20, glutathione production declines steadily dropping by up to 50% by midlife

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Telomerase, also called telomere terminal transferase, is an enzyme made of protein and RNA subunits that elongates chromosomes