A meta-analysis of studies using NAC to increase athletic performance found that there were more side effects (none severe) at 20g/day.[ref] High doses of NAC are used in hospitals by IV for reversing acetaminophen toxicity
It also showed the deleterious effects of intravenous administration of Doxorubicin and Cyclophosphamide against liver and kidney tissues assuming their possible role in cognitive impairment
impact of cholesterol, gender and age
Salas-Ramirez KY, Bagnall C, Frias L, Abdali SA, Ahles TA, Hubbard K (2015) Doxorubicin and cyclophosphamide induce cognitive dysfunction and activate the ERK and AKT signaling pathways
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With respect to side effect recorded following the supplementation, it was found that there was a significantly higher percentage of subjects in the L-carnitine group