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Bibcode:1977PNAS...74.1942J

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Preclinical studies have demonstrated that DPP-4 inhibitors significantly prevent the onset of liver cancer in MC4R-KO mice [111]

Potentially one the most debated points regarding the GLP-1 RA guidelines is how the recommended discontinuation of these medications may impact those with confounding conditions who may truly need them for either obesity management, glycemic control and possible benefits in heart failure, and chronic renal disease