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The onset of T2DM is closely related to the presence of obesity in PWS, the latter related to an insufficient and delayed satiety response, due to uncontrolled food intake mechanisms caused by a hypothalamic dysfunction (192)

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The need of the hour is to have more randomized, double-blind, placebo-controlled trials with a larger sample size, long term follow-up period, with well defined primary and secondary outcomes, targeted to evaluate the efficacy and safety of the skin-lightening effects of topical, oral and parenteral glutathione

Small trials, reports from patients and clinicians, and retrospective studies all point to a powerful anti-addictive effect

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