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Different from mainstream studies focusing on the function of AKR1C3 in hormone-dependent cancers, this review pays more attention to hormone-independent cancers and the combined use of AKR1C3 inhibitors and conventional treatment regimens in antineoplastic protocols

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Ethics statement The requirement of ethical approval was waived by the University of Wisconsin Madison Institutional Review Board for the studies involving humans because this is a retrospective chart review project

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doi: 10.1007/s12011-015-0397-1