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Research shows that the compound enhances pulsatile GH secretion while maintaining physiological rhythm, with experimental studies documenting increases in mean overnight GH levels, average log10 GH peak area, and basal GH secretion rates

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Nausea and Gastrointestinal Effects: Timeline and Management Nausea typically begins within 1-3 days of your first injection and may persist for 2-4 weeks as your body adapts to semaglutide's effects on your digestive system

This evidence supports monitoring rather than ruling out oral contraceptives outright, but individual responses vary significantly

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