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Intramuscular and intranasal administration produced distinct immune readouts, particularly under stress-modulated experimental conditions

Herrera CR, DAgostino RB, Gerstman BB, Bosco LA, Belanger AJ

HO-1 is a stress-induced, anti-inflammatory, immune-modulatory, and cyto-protective enzyme that degrades heme into carbon monoxide, free iron, and biliverdin 47 , consequently, the virus-induced HMRD could compromise host innate and adaptive immune responses

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Tanning requires sustained daily doses of 1.53mg, which activate peripheral melanocortin-1 receptors in melanocytes