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12 GLP-1 RA used in diabetes Commercially available GLP-1RA for management of T2DM Short acting agents Exenatide (twice daily) Exenatide administered by twice-daily subcutaneous injection was the first GLP-1 RA in clinical use

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By chemically tethering the peptide to scaffolds (e.g., chitosan or PEG), researchers can create "bioactive" implants that drive stem cell differentiation toward the chondrogenic lineage

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