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Meaningful immune rebalancing typically requires 3-6 months Tissue repair (TB-500, BPC-157): Varies by tissue type and damage extent, typically 4-12 weeks for meaningful structural improvement Set realistic expectations

The one-carbon metabolic pathway is tightly regulated by intracellular levels of metabolites and cofactors, such as high intracellular SAM levels that activate CBS and inhibit MTHFR, thus shifting hcy levels from transmethylation toward transsulfuration reactions (Finkelstein, 1), and their bioavailability is essential for their function, such as for example in the case of vitamin B12 which is a cofactor of MTR in the synthesis of methionine (Guant et al., 2013)

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