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We show that the cardioprotective actions of GLP-1(2836) do not depend on a functional transmembrane GLP-1R but rather are mediated intracellularly through type 10 soluble adenylyl cyclase (sAC), accompanied by increased cAMP levels, protein kinase A (PKA) activation, and endothelial nitric oxide synthase (eNOS) phosphorylation

Menafra D, de Angelis C, Garifalos F, Mazzella M, Galdiero G, Piscopo M, Castoro M, Verde N, Pivonello C, Simeoli C, Auriemma RS, Colao A, Pivonello R

These findings suggest that glutathione dysfunction may be closely associated with neurodegenerative processes

Some patients use medication short-term, while others continue it for long-term weight management

Beerntsen, B

After the ARPE-19 cells were treated with SI, intracellular free iron levels increased 40-fold, and lipid peroxidation increased significantly