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Chronic studies in cynomolgus monkeys revealed no adverse events at a dose of 20 mg/kg per day [88], and high-dose supplementation in rhesus monkeys caused no ocular toxicity [89]

DOI:10.3389/fphar.2021.627533

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Disulfide bond based polymeric drug carriers for cancer chemotherapy and relevant redox environments in mammals

Despite the use of rodents and small mammals being commonplace in research, in particular for the development of novel therapeutic agents, caution still needs to be practiced when extrapolating research data to clinical applications