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That's because the drug works by targeting three gut hormones, including one called glucagon, which increases energy expenditure

Edvardsson CE, Vestlund J, Ericson M, Jerlhag E

Over time, that lower intake may show up as ongoing fatigue or a general sense of low energy

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Rakipovski G, Rolin B, Nhr J, Klewe I, Frederiksen KS, Augustin R, Hecksher-Srensen J, Ingvorsen C, Polex-Wolf J, Knudsen LB: The GLP-1 Analogs Liraglutide and Semaglutide Reduce Atherosclerosis in ApoE(-/-) and LDLr(-/-) Mice by a Mechanism That Includes Inflammatory Pathways