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doi: 10.3389/fnagi.2020.588044 Received 28 July 2020 Accepted 23 October 2020 Published 24 November 2020 Volume 12 - 2020 Edited by George Tetz, Human Microbiology Institute, United States Reviewed by Vanessa Castelli, University of L'Aquila, Italy

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Frontiers in immunology, 8 , 598

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Intranasal delivery, though less studied with Dihexa, would theoretically provide direct CNS access with minimal systemic exposure, potentially requiring the least frequent administration to maintain effective brain tissue concentrations