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Because that defence reasserts itself when treatment stops the regain seen in STEP 4 (Rubino et al., 2021) and consistent with the roughly four-fifths of lost weight that returns over five years in the older diet literature (Anderson et al., 2001) semaglutide is generally a long-term treatment, not a short course
Losing muscle can lead to falls and fractures
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Implications for insurers Insurers should consider the impact of AOMs across their business: Assess how AOMs may impact protection, morbidity, and longevity experience Review trend assumptions to identify whether changes are needed Establish processes to keep on top of this fast-moving space Consider new lapse risks Assess how AOMs might affect underwriting and claims Insured impacts and reviewing trend assumptions Insurers should consider adjustments to their specific mortality and morbidity improvement assumptions to reflect AOMs