PGH synthetase has two activities, the cyclooxygenase activity which introduces the 5-membered ring into the PUFA (polyunsaturated fatty acid), and another which introduces an endoperoxide and a hydroperoxide into the PUFA
Lifetime Risks of Cardiovascular Disease
doi: 10.1016/j.toxlet.2010.03.330
S., Drobintseva, A
Age : Effects of aging, such as impaired kidney function, can reduce excretion and increase toxic response (when your body cant get the medication out of the bloodstream)
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