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Based on these data, pivotal phase 3 trials comparing icotrokinra with placebo in participants aged 12 years and older with moderate-to-severe plaque psoriasis [ICONIC-LEAD (NCT06095115)] and plaque psoriasis involving difficult-to-treat high-impact sites including scalp, genitals, and hands/feet [ICONIC-TOTAL (NCT06095102)], have been initiated (Table 3)

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Appendix 2 in Supplementary File summarizes some of the most well-known natural substrates of DPP-4 and their corresponding biological functions

The format is convenient and easy to handle during daily bench work

However, it requires strict timing

Small molecules efficiently cross the cell membrane, and they regulate the action of intracellular proteins 123