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After entering the RBC, glucose is immediately converted to glucose-6-phosphate by hexokinase (HK) and then fueled into the glycolytic pathway or into the PPP [182]

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In three different species (i.e., mice, rats, and musk shrews), we show that glucose-dependent insulinotropic polypeptide receptor (GIPR) signaling blocks emesis and attenuates illness behaviors elicited by GLP-1R activation, while maintaining reduced food intake, body weight loss, and improved glucose tolerance

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