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The disruption of mechanisms such as oligodendrocyte maturation and migration, myelin phagocytosis, myelin sheath renewal and the inflammation itself are consonant with the full pathological progression of demyelination

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68 In patients with established CVD, reduced ejection fraction heart failure, or stage 2 or 3 chronic kidney disease, GLP-1 agonists and SGLT-2 inhibitors were shown to be superior to placebo (Table 1) , 1,2,4 and DPP-4 inhibitors were noninferior to placebo 3 for cardiovascular and renal outcomes

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