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Our conclusions would also be strengthened by repeating our analysis with a control group, comparing patients who switched to semaglutide with those who remained on their index GLP-1 RA or who switched to a different GLP-1 RA, such as dulaglutide
Lastly, we examined if ABHD11 could hydrolyze a different acyl chain from lipoate and used a synthetic succinyl-lipoyl (Lp suc ) OGDHc-E2 peptide (Extended Data Fig
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Clinical trials of GLP-1 medications, including the STEP program for semaglutide and SURMOUNT trials for tirzepatide, have documented improvements in physical function scores and quality of life measures
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