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Moreover, the variants exhibited Flex ddG values ranging from 0.8 kcal/mol to 2.4 kcal/mol, implying a limited effect on binding affinity, which might be attributed to variants being distant from protein binding interfaces (Fig

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The compound appears well-tolerated in animals at doses well above those producing metabolic effects

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Some patients even develop atrophic gastritis which can amplify the inability to absorb the nutrients from their foods