The FDA has not yet approved dulaglutide as a weight loss medication
In general, depending on the medical need, commercial insurance and Medicare Advantage plans have also been hesitant to cover the cost of GLP-1s, given they are primarily used for weight loss and carry a hefty price tag
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Common GLP-1 medications include: Ozempic Wegovy Mounjaro Zepbound Some of these medications were initially approved for type 2 diabetes management, while others are FDA-approved specifically for chronic weight management
Moreover, the clinical significance of lean mass loss cannot be inferred solely from quantitative measures, as muscle quality, strength, and metabolic function may be preserved or even improved in some contexts [15,16,17]
As a control, GLP-1 (PDB ID: 1D0R) with the GLP-1 receptor docking analyses, and the HSA-binding DARPin (trRosetta predicted structure) with human serum albumin have been conducted