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Standard angiogenic factors like VEGF primarily accelerate growth without this built-in regulatory mechanism

Lentivirus containing shRNA targeting either a non-specific scramble sequence (sh-C) or specifically targeting NRF2 (sh-NRF2-a and sh-NRF2-b) was used to transduce HaCaT cells

7 , e1002195 (2011)

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Consequently, this nanoplatform leverages multi-component synergy with precisely controlled release, orchestrating dual metabolic reprogramming across tumor cells and the immune landscape, thereby proposing a novel immunometabolic paradigm for lipid balance modulation in the TME

Many are classified as research compounds