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In the presence of elevated blood glucose levels, these agonists bind to GLP1 receptors on pancreatic beta cells, stimulating insulin release [10]

In the VISTA Phase 2b trial targeting obesity and overweight, the 75 mg group showed an average weight loss of 11.8% over 36 weeks

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The mechanism appears to involve both an anti-inflammatory effect on melanocytes and normalization of the barrier function

The decision should be made collaboratively, weighing benefits against side effects