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[18] [19] Situations where dose escalation should be deferred include: persistent gastrointestinal symptoms that haven't resolved, history of severe hypersensitivity reactions, acute pancreatitis during treatment, or patient preference to remain at current dose

difference from placebo for empagliflozin: 1% [95% CI 4%, 1%], p =0.29

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During this six-month interval,earlierparticipantsreported sharp reductions in their feelings of loss-of-control, and in the frequencies of their bingeing episodes

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