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Multi-angle light scattering analysis For multi-angle light-scattering (MALS) measurement, RNF213(371-5207) sample was injected into an AKTA FPLC system (GE Healthcare) with a Superose 6 increase 10/300 GL column with the buffer containing 50 mM HEPES (pH 7.3), 200 mM KCl and 1 mM DTT

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