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Compound 13 significantly inhibited the signal transduction pathway mediated by NF-B in LPS-stimulated murine RAW264.7 macrophages, reducing the expression of pro-inflammatory TNF-, COX-2, IL-1, and IL-6, while also decreasing ROS and NO generation

perform appropriate doseresponse controls

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Detrimental effects of oxidative losses in parkin activity in a model of sporadic Parkinsons disease are attenuated by restoration of PGC1alpha

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