With its localization to the SR, nNOS regulates the S-nitrosylation of the calcium release channels, the type 2 ryanodine receptors (RYR2) resulting in release of stored calcium, The localization of nNOS in the plasma membrane allows for direct S-nitrosylation of L-type Ca 2+ channels resulting in increased influx of calcium

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Aging 2020;12:2134454
It also upregulates actin, a protein critical for cell movement and structure, aiding in faster recovery of muscles and tendons
Slavin, J
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