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It was demonstrated that remission was induced in over 55% of study participants at the highest dose, compared with only 33% of those receiving placebo after 8 weeks, although study failed to reach statistical significance over placebo (Buchman et al

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Third, although the sample size did not differ from the number of patients recruited by Tonin [14], as well as other Authors [11, 15], it should have been larger for a median HbA1c change of 0.3% and a median BMI change of 1.1 kg/m 2

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