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These could involve the GLP-1R, known to signal in anorectic neurons to regulate food intake as well as in -cells to potentiate insulin secretion and -cell survival 67 , as well as other metabolically relevant GPCRs, via VAPB engagement in tissues where this AKAP is expressed, including the pancreas, brain and heart 29,32

Other rare causes of bleeding include post-transplant lymphoma in GI tract and Kaposi sarcoma

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Proteins were either used immediately for biochemical assays or flash-frozen in liquid nitrogen and stored at 80 C for future use