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PMC 3474193
& Kulkarni, G
Epitalon also appears to modulate gene expression , particularly those related to oxidative stress response and inflammation both of which are critical components in the development of age-associated diseases
In 1967, Luzzatto 12 postulated at least two sites of union of the NADP to the enzyme, with a condition of transition from low to high affinity when NADPs concentration increases, which means that there exist two possible forms of the enzyme, according to its affinity by the NADP
However, further investigations in larger populations are required to confirm the contribution of the GPX4 gene to the risk of CS, and to assess the relationship between the GPX4 genotype and the enzyme expression/activity
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