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and the Lys 26 side chain is prepared by fragmental synthesis, and a fully-protected fragment of Fmoc-PEG-PEG--Glu-octadecanedioic acid used in the fragmental synthesis of the Lys 26 side chain is prepared by successively coupling a chloride resin to Fmoc-PEG-OH, Fmoc-PEG-OH, Fmoc-Glu(OH)-OtBu and octadecanedioic acid mono-tert-butyl ester, cleaving, and recrystallizing to obtain PEG-PEG--Glu-Octadecanedioic Acid mono-tert-butyl ester

10.2337/dc19-0898 Summary Keywords GLP-1 receptor agonists, type 2 diabetes mellitus, gastrointestinal adverse events, Bayesian network meta-analysis, nausea, vomiting, diarrhea Citation Xie X, Yang S, Deng S, Liu Y, Xu Z and He B (2025) Comparative gastrointestinal adverse effects of GLP-1 receptor agonists and multi-target analogs in type 2 diabetes: a Bayesian network meta-analysis