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Additionally, the SURMOUNT-1 trial found that 95% of people with obesity who also had prediabetes and took tirzepatide reverted to normal glucose levels

Serious side effects are extremely uncommon , especially with intramuscular (IM) and IV administration using clinically appropriate doses

In addition to its role in UPR-driven transcriptional changes via XBP1 splicing, IRE1 is involved in the regulated IRE1-dependent mRNA decay (RIDD) to halt further translation, thereby inhibiting excessive protein burden in the ER and ensuring proteostasis under conditions of ER stress

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Or is this just another trend dressed up in science-y language