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We found that this modest increase in homocysteine correlated with a decrease in endothelium-dependent vasodilation both in isolated aortic rings as well as in situ mesenteric micro-vessels from CBS +/ mice [59, 61]

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(2023) "Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes" The New England Journal of Medicine, 389(24) This article was reviewed by and approved by Alice Fletcher, Lead Bariatric Dietitian, on 3 April 2025

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SURMOUNT-MAINTAIN randomized patients who had lost weight on the maximum dose of tirzepatide to either continue at full dose of 10 or 15 mg, reduce to 5 mg, or switch to placebo for an additional year