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[40] [41] Contraindications [edit] Semaglutide is contraindicated in people with a personal or family history of medullary thyroid carcinoma or in people with multiple endocrine neoplasia type 2

Pros Cons : What your doctor might consider Side effects Across all GLP-1s, around one in four people experience nausea, bloating, diarrhea, or constipation

Native GLP-1 is not suitable for treatment, since the peptide is degraded rapidly within minutes by the enzyme dipeptidyl-peptidase-IV (DPP-4) (31, 32)

Anti-HCV IgM are found in 50%-93% of patients with acute hepatitis C, but also in 50-70% of patients with chronic hepatitis C.20-22 Therefore, anti-HCV IgM cannot be used as a reliable marker of acute HCV infection

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The most common adverse events reported with oral semaglutide were mild-to-moderate transient gastrointestinal eventsa finding consistent with the known tolerability of other available GLP-1 receptor agonists