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HGH is produced by the pituitary gland and acts as a master hormone, stimulating the liver to produce IGF-1

This is also in line with a study in older 16 months old APOE-TR mice which found the same pattern of decreased LCAs and increased SCAs in E4s compared to E3s, particularly in males (Shang et al., 2020)

GHRH family analogues: initiating GH gene transcription Endogenous growth hormone-releasing hormone (GHRH) is a 44-amino-acid hypothalamic hormone that directs the release of GH by somatotroph cells of the anterior pituitary gland

PMID: 107 ChenCChenJWangYLiuZWuY

Do the benefits outweigh the potential side-effects

Understanding your susceptibility can help you prioritize lifestyle and diet changes