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doi: 10.5758/vsi.2014.30.4.113

Albumin uptake in neurons heightens NMDA receptor excitability, provoking glutamate excitotoxicity that exacerbates myelin and oligodendrocyte injury, culminating in neuronal apoptosis [281, 282]

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The removal of this region and the multivalent presentation on a ferritin nanoparticle significantly improved DCFHPs neutralizing potency in mice relative to the use of unedited spike, since it allows the immune system to not get distracted by creating an antibody response against a region that is ultimately nonneutralizing [134]

In such cases, lower doses are often useful to monitor tolerance

Szopa A, Ekiert R, Ekiert H