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Freeman LR, Zhang L, Nair A, Dasuri K, Francis J, Fernandez-Kim SO, Bruce-Keller AJ, Keller JN (2013) Obesity increases cerebrocortical reactive oxygen species and impairs brain function

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The compound operates through a unique triple mechanism: inhibiting the reuptake of norepinephrine (NET), dopamine (DAT), and serotonin (SERT) transporters with IC50 values of 1.7 nM, 65 nM, and 11 nM respectively

Arg 43* forms water-mediated hydrogen bond interactions with Tyr 32 and Tyr 50 (CDR1 VL and CDR2 VL)

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