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Abbreviations AD-MSCs: Adipose-derived mesenchymal stem cells ADPKD: Autosomal dominant polycystic kidney disease AE: Adverse events BM-MSCs: Bone marrow-derived mesenchymal stem cells BUN: Blood urea nitrogen C3: Complement C3 C4: Complement C4 CAT: Catalase CCL: Chemokine (CC motif) ligand CD: Cluster of differentiation CKD: Chronic kidney disease CXCL: Chemokine (C-X-C motif) ligand DCs: Dendritic cells DN: Diabetic nephropathy ESRD: End-stage renal disease FGF: Fibroblast growth factor FLT3/FLT3L: FMS-like tyrosine kinase 3/ Fms-related tyrosine kinase 3 ligand FOXP3: Forkhead box P3 GFR: Glomerular filtration rate GPx: Glutathione peroxidase GSH: Glutathione GSTs: Glutathione Stransferases HGF: Hepatocyte growth factor HIF: Hypoxia-inducible factor HO1: Heme oxygenase1 IDO: Indoleamine 2,3 dioxygenase IGF-1: Insulin-like growth factor 1 IFN-: Interferon- IL: Interleukin IN: Ischemic Nephropathy LN: Lupus nephritis MAPK: Mitogen activated protein kinase MCP-1: Monocyte chemoattractant protein-1 M-CSF: Macrophagecolony stimulating factor miR: MicroRNA MSCs: Mesenchymal stem cells NKs: Natural killer cells NO: Nitric oxide Nrf2: Nuclear factor erythroid 2related factor 2 PDGF: Platelet-derived growth factor PGE 2 : prostaglandin E2 PI3K: Phosphoinositide 3-kinase RBF: Renal blood flow RRI: Renal resistive index SAE: Serious adverse events SCr: Serum creatinine SDF-1: Stromal cell-derived factor-1 SLE: Systemic lupus erythematosus SOD: Superoxide dismutase Tfh: follicular helper T cells TGF-: Transforming growth factor- Th: Helper T cells TNF-: Tumor necrosis factor- Tregs: Regulatory T cells UC-MSCs: Umbilical cord-derived mesenchymal stem cells VEGF: Vascular endothelial growth factor References Kalantar-Zadeh K, Jafar TH, Nitsch D, Neuen BL, Perkovic V

Critical Reviews in Toxicology 44:24469

Thats why weve built our entire operation around small-batch synthesis

Igf1 , insulin-like growth factor 1