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The best reference point is oral semaglutide, because it is the only GLP-1 receptor agonist that has been successfully formulated as an oral tablet and approved by the FDA

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Ongoing research is expected to expand the list of TCM-derived metabolites with evidence-based benefits, to optimize their formulations (for example, improving bioavailability of poorly absorbed molecules), and to clarify their roles in practice (whether as adjuncts to standard therapy to address residual risks like inflammation, or as alternatives in specific scenarios such as statin-intolerant patients)