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Pathogen-associated molecular patterns, such as lipopolysaccharide (LPS), bacterial or viral DNA, and some cytokines (i.e., IFN), induce polarization toward pro-inflammatory (M1-like) macrophages via STAT1, NF-B, and IFN regulatory factor transcription factor signaling, resulting in augmented pro-inflammatory cytokine production (e.g., IL6, IL1, IL8, IL33, TNF-, and IFN-1) [105,106,107]

Most patients had comorbid pathology [hypertension, cerebrovascular diseases (CVDs), cardiovascular disease, and diabetes] and had been mentally ill for many years/decades (Table 1)

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The GO improvement following treatment with selenium was maintained also at 12 months, suggesting that the beneficial effect of selenium is persistent after treatment withdrawal

de Oliveira CMB, Sakata RK, Issy AM, Garcia JBS (2004) Cetamina e analgesia preemptiva